pain

An ache or bodily suffering, or an instance of this; an unpleasant sensation, resulting from a derangement of functions, disease, or injury by violence; hurt.

"I had to stop running when I started getting pains in my feet."

The condition or fact of suffering or anguish especially mental, as opposed to pleasure; torment; distress

"In the final analysis, pain is a fact of life."

(from pain in the neck) An annoying person or thing.

"Your mother is a right pain."

To hurt; to put to bodily uneasiness or anguish; to afflict with uneasy sensations of any degree of intensity; to torment; to torture.

"The wound pained him."

To render uneasy in mind; to disquiet; to distress; to grieve.

"It pains me to say that I must let you go."

To inflict suffering upon as a penalty; to punish.