bitch

(dog-breeding) A female dog or other canine, particularly a recent mother.

"My bitch just had puppies; they're so cute!"

A promiscuous woman, slut, whore.

A despicable or disagreeable, aggressive person, usually a woman.

"Ann gossiped about me and mocked my work; sometimes she can be a real bitch!"

To behave or act as a bitch.

To criticize spitefully, often for the sake of complaining rather than in order to have the problem corrected.

"All you ever do is bitch about the food I cook for you!"

To spoil, to ruin.